Some people look for alternative medications to Hydroxyzine because they’re experiencing unwanted side effects — like drowsiness, dry mouth, or dizziness — while others might need a different option due to cost, lack of accessibility, or efficacy, or a personal preference for a more natural approach to treating their symptoms.
Fortunately, there are many Hydroxyzine alternatives for anxiety treatment, including a wide range of both pharmaceutical and more natural options. If you’re thinking about altering your treatment plan, it’s important that you talk to your health provider to figure out the best path moving forward together. Read on to learn more about substitutes for Hydroxyzine.
Alternative Medications to Hydroxyzine
If Hydroxyzine isn’t working the way you want it to, or if you want a change for any other reason, rest assured, there are plenty of other medications you can try. Different drugs will target anxiety using different mechanisms than Hydroxyzine, so they might be a better fit. Reach out to your doctor or mental health provider as you explore new medications. They’re your best chance at finding a treatment plan that aligns with your symptoms, condition, lifestyle, and preferences.
| Name | Generic name | Class of drug | Conditions treated | Top side effects |
| Buspirone | Buspirone | Anti-Anxiety Agent | Generalized anxiety disorder | Dizziness, headache, nausea |
| Zoloft | Sertraline | SSRI | Anxiety, depression | Nausea, weight gain, insomnia |
| Lexapro | Escitalopram | SSRI | Anxiety, depression | Dizziness, headache, nausea |
| Effexor XR | Venlafaxine | SNRI | Anxiety | Nausea, dry mouth, dizziness, constipation, insomnia, hypertension |
| Cymbalta | Duloxetine | SNRI | Anxiety,chronic pain, depression | Sweating, insomnia, fatigue |
| Ativan | Lorazepam | Benzodiazepine | Acute anxiety | Sedation, dizziness, dependency |
| Xanax | Alprazolam | Benzodiazepine | Acute anxiety | Drowsiness, light-headedness, confusion, dizziness, slurred speech, dry mouth, blurred vision |
| Propranolol | Propranolol | Beta-Blocker | Situational anxiety | Fatigue, dizziness, cold extremities |
Buspirone
Buspirone is an anti-anxiety drug that’s also designed to treat generalized anxiety disorder (GAD). It differs from Hydroxyzine, though, as it has no major sedative effects. Buspirone is also better suited for long-term use. While Buspirone does have side effects like dizziness, headache, and nausea, studies indicate that it has fewer side effects than some other anti-anxiety drugs.
If you’re interested in this alternative, learn more about Buspirone vs. Hydroxyzine.
SSRIs
Selective serotonin reuptake inhibitors (SSRIs) — like Zoloft (sertraline) and Lexapro (escitalopram) — are commonly used to treat anxiety and depression. These drugs work by increasing serotonin levels in the brain, which improves mood and reduces anxiety symptoms. Note that it can take between 4 – 6 weeks to see any noticeable effects from an SSRI.
The most common reactions and side effects of SSRIs can include sexual dysfunction, sleepiness, and weight gain.
SNRIs
Serotonin and norepinephrine reuptake inhibitors (SNRIs) like Effexor XR (venlafaxine) and Cymbalta (duloxetine) are also effective in treating anxiety disorders. SNRIs work by increasing serotonin and norepinephrine levels in the brain to regulate mood and diminish anxiety symptoms, offering relief.
Benzodiazepines
Benzodiazepines like Ativan (lorazepam) and Xanax (alprazolam) are fast-acting drugs that are beneficial for treating acute anxiety episodes. Benzodiazepines enhance the calming effects of GABA, another neurotransmitter in the brain.
Benzodiazepine side effects can include drowsiness, light-headedness, confusion, dizziness, slurred speech, muscle weakness, dry mouth, blurred vision, and memory problems. In addition to the side effects, benzodiazepines have a higher risk of addiction, so they are usually intended for short-term use only. Be sure to research the differences between Hydroxyzine and Xanax to find the best treatment for your condition.
Beta-blockers
Natural/Non-Pharmaceutical Alternatives to Hydroxyzine
Some people don’t want to rely on medication to manage their anxiety. They might be looking for a natural alternative or non-pharmaceutical approach to avoid the side effects of Hydroxyzine or other anxiety medications. From structured therapeutic methods to holistic practices, there are numerous treatments tailored to individual preferences and needs, either as standalone solutions or as a combined care component.
Cognitive behavioral therapy (CBT)
Cognitive behavioral therapy (CBT) is a type of psychotherapy (also known as talk therapy) that helps you identify and challenge negative, unhealthy, or unhelpful thought patterns that can be contributing to your anxiety. Numerous studies confirm CBT’s efficacy for conditions like generalized anxiety disorder and other stress-related disorders. CBT for anxiety can be done in person or online, offering flexibility and convenience for busy individuals.
Acupuncture
Acupuncture, a centuries-old Chinese practice, involves the precise placement of ultra-thin needles at specific pressure points to restore balance and harmony to the body’s energy flow. But it’s not just about tradition—modern research highlights its potential to effectively ease anxiety symptoms. Although more studies are needed to fully understand the benefits of acupuncture for anxiety, it continues to be a sought-after, holistic treatment approach for those looking to find calm and balance in their lives.
Lifestyle adjustments
Simple lifestyle changes can have a big impact on managing anxiety. Regular exercise boosts endorphins, lifting your mood and enhancing overall well-being. Prioritizing quality sleep with a consistent schedule supports emotional regulation, while a balanced diet provides the nutrients your mind and body need to thrive. Cutting back on caffeine and alcohol can also make a noticeable difference, helping to reduce symptoms.
Herbal remedies
Here are some of the most notable options:
- Rhodiola rosea: An adaptogenic herb known for its ability to help the body manage stress effectively
- Ashwagandha: A widely-used herb from Asia and Africa that’s celebrated for reducing anxiety and anxiety
- St. John’s wort: Often studied for its potential to improve mood and ease anxiety symptoms
- Valerian root: Popular for its calming effects, especially when paired with sleep support.
- Passionflower: A gentle herb believed to reduce anxiety and encourage relaxation
Always speak with your healthcare provider before trying herbal remedies, particularly St. John’s wort and valerian root, as they can interact poorly with medications and may not be safe for everyone.
Supplements
Supplements are a popular option for those looking to help manage anxiety naturally. Here are some of the most well-known supplements and how they may help:
- Magnesium: Known for supporting healthy nerve function, magnesium may help reduce anxiety by calming the nervous system.
- Omega-3 fatty acids: Found in fish oil and certain plant-based oils, omega-3s have been shown to reduce anxiety symptoms and lower cortisol levels, especially during high-stress moments.
- L-theanine: A compound commonly found in green tea, L-theanine promotes relaxation and a sense of calm without causing drowsiness or sedation.
“Supplements such as magnesium, L-theanine, and valerian root may help with symptoms that Hydroxyzine addresses, including anxiety and sleep disturbances. Make sure to consult with a healthcare professional before starting any of these supplements to ensure safety and effectiveness.”
– Talkspace therapist Bisma Anwar, LPC, LMHC
Considerations When Choosing a Hydroxyzine Alternative
If you’re looking for a substitute for Hydroxyzine, you should consider multiple factors.
Think about the following before you make a decision:
- Personal health history: Discuss pre-existing conditions, other medications you’re currently taking, allergies, or sensitivities with your doctor or healthcare provider.
- Side effects: Almost all drugs and treatments have a risk of side effects.
- Cost and accessibility: Financial considerations can impact some types of treatments.
- Lifestyle compatibility: Some options might require adjustments to your daily routines.
Work with your healthcare provider to ensure you’re crafting a safe and effective anxiety treatment plan. Discuss your symptoms, medical history, and preferences, and then you can develop a plan that’s explicitly tailored to your exact needs. Before you stop taking your current Hydroxyzine prescription, talk to a doctor to avoid the possible chance of Hydroxyzine withdrawal.
Find the Right Hydroxyzine Alternative with Talkspace
Trying to find an alternative anxiety treatment can be overwhelming, but the good news is you don’t have to do it alone. With Talkspace, you’ll be connected with a licensed, experienced psychiatric provider who can help you explore Hydroxyzine alternatives, manage your medications, and develop a comprehensive, effective treatment plan.
Whether you’re seeking medication management, therapy, or natural remedies, Talkspace offers convenient and secure online mental health care. Reach out to connect with an online psychiatrist to learn more about alternatives to Hydroxyzine for anxiety today.
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