Seroquel Withdrawal: All You Need to Know

Seroquel (quetiapine) is commonly prescribed to treat conditions like schizophrenia, bipolar disorder, and depression. This antipsychotic helps manage symptoms but requires careful handling during cessation. Trying to come off it can be an adjustment to your body and mind. Abruptly stopping this medication can lead to Seroquel withdrawal, which causes symptoms ranging from physical discomfort to emotional imbalance. Common Seroquel withdrawal symptoms can include insomnia, irritability, nausea, increased heart rate, and mood swings. 

There are several reasons you might consider stopping Seroquel, such as unwanted Seroquel side effects, trying a different antipsychotic treatment, or personal preference. Whatever the reason, safely stopping any antipsychotic medication takes careful planning and professional guidance from your doctor or a mental health professional. 

It’s crucial to address both physical and psychological aspects during the process of Seroquel withdrawal. Keep reading to learn how to avoid Seroquel withdrawal effects​ if you’re planning on discontinuing this drug. 

Can You Stop Taking Seroquel Immediately?

The short answer is no — you should not stop taking Seroquel suddenly. Stopping this antipsychotic medication cold turkey can cause intense symptoms of withdrawal. You might experience heightened anxiety, severe mood swings, or even physical ailments like nausea or dizziness. 

Abrupt discontinuation of Seroquel can also cause what’s known as a “rebound effect,” where some of the original symptoms that Seroquel was managing return with much greater intensity, like a relapse of psychosis. If you’re considering a switch, understanding the differences in efficacy and side effects between Seroquel and Abilify or other alternatives can guide your decision-making process.

To reduce the risks of withdrawal, consult a doctor to discuss a tailored tapering schedule. A managed taper is crucial to handle the antipsychotic discontinuation effectively. Gradually reducing your dosage can minimize or avoid Seroquel withdrawal effects.

Withdrawal Symptoms of Seroquel

When you stop taking Seroquel, the impact can vary from person to person. Withdrawal symptoms can be categorized into physical or emotional symptoms.

Physical symptoms of withdrawal from Seroquel​ can include:

  • Nausea or vomiting
  • Headaches
  • Dizziness or lightheadedness
  • Fatigue
  • Sweating or chills
  • Restlessness or tremors

Emotional symptoms of withdrawal from Seroquel​ can include:

  • Anxiety
  • Irritability or agitation
  • Insomnia or disturbed sleep patterns
  • Depression
  • Mood swings
  • Difficulty concentrating
  • Suicidal thoughts

Knowing the major Seroquel withdrawal symptoms is important. If you experience any of them, you can quickly seek help, find appropriate interventions, and manage your transition more effectively and safely. Remember, seeking professional help early in the treatment process can prevent worsening symptoms.

How Long Does Seroquel Withdrawal Last?

The timeline for Seroquel withdrawal widely varies from one person to the next. For some people, symptoms might begin within 24 to 48 hours after stopping the medication and last for a few days to a week. For others, the effects can go on for several weeks, especially for long-term users or someone on a higher dose treatment. 

Factors that can influence how long Seroquel withdrawal last​s:

  • Dosage: Higher doses can lead to more prolonged withdrawal effects in some people.
  • Length of use: Long-term use can mean a more extended withdrawal period.
  • Individual differences: Individual body chemistry and health can affect withdrawal timelines.

Most people will experience some form of withdrawal symptoms as they quit taking Seroquel, but with a gradual taper schedule, the severity can be drastically minimized. It’s important to stay in touch with your psychiatrist or doctor throughout the tapering process so they can monitor your progress and promptly address any concerns, issues, or discomfort. Frequent consultation and support from psychiatric professionals can aid in recovery and reduce symptoms.

Managing Seroquel Withdrawal Symptoms

Coping with symptoms of withdrawal from Seroquel can feel overwhelming, but fortunately, there are some strategies you can use to ease the process. 

Tips for reducing Seroquel withdrawal symptoms:

“When tapering off Seroquel, reduce your dosage gradually under a doctor’s supervision to minimize withdrawal symptoms like insomnia or anxiety. Stay hydrated, maintain a consistent sleep routine, and use mindfulness practices to help manage mood changes.”

Talkspace therapist Bisma Anwar, LPC, LMHC 

How Do I Safely Come Off Seroquel?

Using a tapering schedule created by your doctor is the safest and most effective method for discontinuing Seroquel without significant withdrawal symptoms. Gradually reducing your dosage helps your body and system adjust over time — so using a slow tapered process can significantly reduce the risk of severe Seroquel withdrawal effects. 

“Tapering is the best method for coming off Seroquel. Stopping abruptly can cause a sudden chemical imbalance, leading to more severe side effects and potential relapse.”

Talkspace therapist Bisma Anwar, LPC, LMHC 

Your healthcare provider will design an antipsychotic medication tapering plan that’s tailored to your exact treatment needs and condition. They’ll consider factors like:

  • Your current dose
  • How long you’ve been taking the medication
  • Other comorbid conditions
  • Other drugs you’re taking
  • Your mental health history
  • Your overall current health

Talk with a Licensed Psychiatrist

Stopping Seroquel can be a challenging process, but you don’t have to do it alone. With the help of a doctor, licensed psychiatrist, or other mental health professional, you can slowly and safely quit taking this antipsychotic medication, explore Seroquel alternatives or other treatments, and address any severe or lingering symptoms you might be experiencing.

Talkspace offers convenient, affordable access to online psychiatric providers who provide expert advice in response to your situation. If you’re thinking about stopping Seroquel or you need help managing withdrawal symptoms, Talkspace is there to support you every step of the way. Talkspace prescribes Seroquel and alternatives online, so you have options.

Contact an online psychiatrist at Talkspace today to learn more about creating a structured treatment plan. This plan will help facilitate the detox process and mitigate risks.

Sources:

  1. Quetiapine: MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a698019.html. Accessed December 19, 2024.
  2. Monahan K, Cuzens-Sutton J, Siskind D, Kisely S. Quetiapine withdrawal: A systematic review. Australian & New Zealand Journal of Psychiatry. 2020;55(8):772-783. doi:10.1177/0004867420965693. https://pubmed.ncbi.nlm.nih.gov/33059460/. Accessed December 19, 2024.

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