Side Effects of Seroquel to Be Aware of

Seroquel (quetiapine) is a prescription medicine in the class of drugs known as atypical antipsychotics. Studies show its effectiveness as it is commonly used to treat several mental health and psychiatric conditions, like schizophrenia, depression, and bipolar disorder. Like all medications, Seroquel has potential side effects and symptoms that users must understand to take it safely and effectively.

Being informed about Seroquel side effects ensures you can quickly recognize changes in your body due to the medication. That means you can discuss concerns with your healthcare provider or a mental health professional. If you’re thinking about starting or currently take this medicine, make sure you talk to your doctor about possible side effects, so you know what to expect. 

Read on to learn more about the side effects of Seroquel​ so you can determine if it’s a suitable antipsychotic medication for your condition and needs. 

Common Side Effects You Might Expect While on Seroquel

It’s common to experience at least some Seroquel side effects​, especially during the first few weeks as your body adjusts to the new medication. Knowing what to expect will help you navigate this period and manage your antipsychotic treatment better. It can also help you decide whether to seek professional advice. 

Week-by-week expectations:

• Week 1: The medication is generally well-tolerated with some common side effects like mild drowsiness, dry mouth, and dizziness.
• Week 2: You might notice increased appetite at this point.
• Week 3 and beyond: Most side effects will eventually subside, but for others, things like sedation or weight gain can continue.

Below are some of the more frequently reported Seroquel side effects experienced during clinical trials. 

• Drowsiness or sedation 
• Feeling tired or weak
• Dry mouth
• Stuffy nose
• Difficulty moving
• Dizziness or lightheadedness
• Increased appetite
• Weight gain
• Constipation
• Nausea 
• Fatigue
• Sore throat
• Abnormal liver function tests

”With Seroquel, sedation is the most prominent side effect. Stimulation of appetite can lead to weight changes. There is a need to monitor the metabolic profile, including blood sugar and lipid profile. Having a healthy lifestyle, exercise, and eating habits is essential while taking Seroquel.”

– Talkspace psychiatrist Dr. Muhammad Munir

Regular consultation with your doctor is vital throughout your treatment with this medicine to address any emerging side effects listed above or health concerns related to this antipsychotic. If any of these common side effects persist or worsen, contact a healthcare provider to discuss them. Only your doctor can determine if you should change dosage or consider a different medication.

How Long Do Seroquel Side Effects Last?

How long Seroquel’s side effects last can vary depending on factors like the dosage and the individual taking it. The short-term side effects, like drowsiness and dizziness, often improve within days or weeks as your body adjusts to the dose. However, other side effects, like weight gain or metabolic changes, might last as long as you take Seroquel. 

Less Common Side Effects of Seroquel

It’s possible to experience less common side effects when taking Seroquel. While they generally occur less frequently, being aware of them is still important in understanding how this medicine might affect you. If you notice any of the following side effects after starting Seroquel, notify your healthcare provider to determine the best course of action.

• Blurred vision
• Change in appetite
• Heartburn
• Decreased strength
• Less energy
• Indigestion
• Increased sweating
• Sneezing
• Runny nose
• Upset stomach

Serious Side Effects of Seroquel

For most users, Seroquel is well-tolerated. However, it can occasionally cause severe side effects in some people. These effects are significant considerations when taking this antipsychotic drug.

If you experience any of the following serious side effects of Seroquel, seek immediate medical attention:

• Severe allergic reaction: Symptoms of a serious allergic reaction to Seroquel may include wheezing, a racing heart, fever, and swelling of the lips, mouth, face, throat, or tongue. Seek immediate medical attention if these occur.
• Tardive dyskinesia: A serious condition characterized by involuntary, repetitive movements, particularly of the face and limbs. These movements may become permanent with prolonged use of Seroquel.
• Metabolic changes: Seroquel may cause significant weight gain, increased blood sugar levels, or diabetes. Symptoms of diabetes can include increased thirst, frequent urination, and fatigue. Severe cases may lead to coma or death.
• Low blood pressure: Seroquel can cause a sudden drop in blood pressure, particularly when standing up too quickly, leading to dizziness, fainting, or falls.
• Neuroleptic malignant syndrome (NMS): A rare but life-threatening condition that may occur with Seroquel use. Symptoms include severe muscle rigidity, high fever, confusion, and altered mental status. Seek emergency medical care if these symptoms appear.
• Body temperature regulation: Seroquel can interfere with the body’s ability to regulate temperature, increasing the risk of overheating, especially during hot weather or physical activity. Stay hydrated and avoid overheating to reduce the risk of dehydration.
• Sedation: Seroquel may cause excessive drowsiness that can interfere with daily activities or basic functioning. If affected, avoid operating heavy machinery or driving.

Long-Term Side Effects and Considerations

Prolonged use can lead to long-term side effects of Seroquel, some of which may require ongoing management or intervention.  

Weight gain

Seroquel can increase appetite, leading to significant weight gain over long-term treatment with this antipsychotic drug. This may elevate the risk of obesity-related conditions such as diabetes and heart disease.

Increased blood sugar

Long-term Seroquel use can elevate blood sugar levels, which can lead to type 2 diabetes in some people. Thus, to ensure safety, regular glucose monitoring is standard when using this antipsychotic medicine for long periods.

Elevated cholesterol levels

Research shows a link between Seroquel and high cholesterol levels, although the cause isn’t fully understood. High cholesterol can increase the risk of heart disease and other cardiovascular issues, which is why your doctor might suggest routine blood tests if you’re taking Seroquel. If there is a concern, they might discuss dietary changes or new medications to manage your levels.

Chronic sedation and drowsiness

Some people who use Seroquel experience ongoing sedation that can impact their daily functioning and quality of life. Your doctor might have you adjust the timing of doses or suggest you explore alternative medications to help.

Tardive dyskinesia

Tardive dyskinesia is a rare movement disorder that can become permanent if untreated. It’s characterized by involuntary, abnormal muscle movements that you should report to your healthcare provider as soon as you notice them.

In some cases, discontinuing Seroquel may help alleviate symptoms, but stopping the medication should only be done under a doctor’s supervision. Treatment options for tardive dyskinesia may include switching to a different medication or prescribing medications specifically designed to manage the condition, such as valbenazine or deutetrabenazine. It’s crucial to work closely with your healthcare provider to determine the best course of action.

Neuroleptic malignant syndrome (NMS)

Though very uncommon, NMS is a serious condition that warrants close monitoring and immediate intervention if symptoms appear. Routine check-ups and open communication with your healthcare provider are key to mitigating risk. 

Symptoms of NMS can include:

• High fever (102–104°F)
• Muscle rigidity
• Irregular heartbeat or excessive sweating
• Altered mental state
• Laboratory abnormalities

Managing Side Effects with Your Healthcare Provider

It’s usually possible to effectively manage Seroquel side effects by working with your healthcare provider. To reduce the risk of experiencing unwanted side effects, always take Seroquel exactly as directed. Never alter or skip doses without talking to your doctor first, as doing so could lead to Seroquel withdrawal. 

Tips for managing unwanted side effects of Seroquel include:

• Adjusting the dose: A lower dose may alleviate some side effects.
• Incorporating lifestyle changes: Making small lifestyle adjustments can help manage side effects. For example, maintaining a balanced diet can help combat weight gain, engaging in regular physical activity can boost energy levels and support cardiovascular health, and establishing a consistent sleep routine can reduce drowsiness.
• Using supportive treatments: For some side effects, over-the-counter remedies like stool softeners for constipation can offer relief.
• Scheduling regular check-ups: Routine blood tests and physical exams are essential in monitoring metabolic changes and other long-term side effects of Seroquel.
• Switching medications: In some cases, an alternative medication might be a better fit. Comparing medications like Abilify vs Seroquel can help you find the best treatment option for your specific mental health condition.

“The dose of Seroquel needs to be adjusted to address the clinical symptoms in keeping with the side effect profile. A healthy diet, exercise, and regular monitoring of the lipid profile and blood sugar changes are an essential part of treatment. Once moods stabilize, reducing the dose is also a consideration.”

– Talkspace psychiatrist Dr. Muhammad Munir

See If Seroquel Is Right for You with Talkspace 

While it can be an effective treatment for managing several mental health conditions, you must understand and address potential Seroquel side effects for safe and successful use. You can minimize the risks associated with this medication by staying informed, working closely with your healthcare provider, and making occasional lifestyle adjustments.

If you’re considering this medication, Seroquel alternatives, or any prescription medication to help your mental health, and you want support in managing side effects, Talkspace offers online psychiatry and medication management to guide you. Talkspace providers offer expert advice and personalized care.  

Get Seroquel prescribed online by a Talkspace psychiatrist and take the first step toward better mental health. Check out Talkspace online psychiatry today to learn more.